USPTO Patents Application 10773398

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CI

Andersson, M. A., et al., "Analysis of Type 11 Collagen Reactive T Ceils in the Mouse** Scand. J. Immunol,
Vol.33, pp. 505-510(1991)

C2

Miyahara, H., et al., "Identification and Characterization of a Major Tolerogenic T-cell Epitope of Type 11
Collaqen that Suppresses Arthritis in B10.RIII Mice". Immunology. Vol. 86. pp. 110-115 (1995)

C3

Nabozny, G.H., et al.. "identification of a Cyanooen Bromide Fragment of Porcine Type 11 Collagen Capable
of Modulating Collaqen Arthritis in B10.RIII (H2^Mice^'* Autoimmunity Vol 20. pp. 39-49

C4

KenA^ar, S.S., et al., "Type II Collagen Induced Arthritis in Rats: Clinical and Immunological Studies", Int. J.
Tiss. Reac. Vol. Vll(6). pp. 409-429

C5

Rowley, M.J.. et al., "Epitope Specificty of Antibodies to Type 11 Collegan in Rheumatoid Arthritis and
Systemic Lupu Erythematosus', Rheumatology International. Vol. 12(2), pp. 65-69.

C6

Boissier, M.C.. et al., "Role De La Conformation Du Collagene Dans L'Immunite Anti-Collagene De Type 11
Au Cours De La Polyarthrite Rhumatoide". Revue du Rhumatisme, Vol. 58(1). pp. 19-24 (1991)

07

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OTHER DOCUMENTS (Including Author. Title. Date. Pertinent Pages. Etc.)

Bornstein, P. and Sage, H. (1980). Structurally distinct collagen Types. Ann. Rev. Biocheni. 49:957-1003.

Brodsky. B. and Shah. N,K. (1995). The triple-helix motif in proteins FASEB J. 9:1537-1546

Buckee. C, Morgan. K., Ayad. S.. Collins, I., Clague, R.B., Holl. P.J.L. (1990). Diversity of antibodies to type II
collagen in patients with rheunnatoid arthritis: detection by binding to -chains and to cyanogen bromide
peptides. Brit J. Rheumatol. 29:254-258

Charriere. G., Hartmann. D.J., Vignon. E., Ronziere. M-C, Herbage D., Ville. G. (1988). Antibodies to types I,
II. IX. and XI collagen in the serum of patients with rheumatic diseases. Arthritis Rheum. 31 :325-332.

Choi, E.K.K,, Gatenby. P.A,. McGill. N.W.. Bateman. J.F.. Cole. W.G,. York, J.R. (1988). Autoantibodies to
type II collagen: occurrence in rheumatoid arthritis, other arthritides. autoimmune connective diseases, and
chronic inflammatory syndromes. Ann. Rheum. Dis. 47:313-322.

Clague, R.B., Shaw, M.J.. Holt. P.J.L. (1980). Incidence of serum antibodies to native type I and type II
collagen in patients with Inflammatory arthritis . Ann. Rheum. Dis. 39:201-206.

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Draw line through citation if not in conformance and not considered. Include any copy of this form
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002.1147358.1

Form PT0.1449 U.S. DEPARTMENT OF COMMERCE
(MODIFIED) PATENT AND TRADEMARK OFFICE

INFORMATION DISCLOSURE CITATION

(Use several sheets if necessary)

ATTY. DOCKET NO.

017227/0197

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APPLICANT

Andrew COOK et al.

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OTHER DOCUMENTS (I r)cludmg Author, Title, Date, Pertlner)t Pages, Etc.)

Collier, D.H., Kerwar, S.S., Garovoy, M.R., Fye, K.H., Stobo, J.D. (1984). Anticollagen antibodies and immune
response gene products in rheumatoid arthritis. Arthritis Rheum, 27:1201-1209.

Cook. A.D.. Rowley. M.J.. Stockman. A., Mulrden, K.D., Mackay. I.R. (1994). Specificity of antibodies of type II
collagen in earty riieumatoid arthritis. J. Rheumatol. 21:1186-1191.

Cook. A.D.. Rowley. M.J.. Mackay, I.R.. Gough, A., Emery. P. (1996). Antibodies to type II collagen in early
rheumatoid arthritis: correlation with disease progression. Arthritis Rheum 39:1720-1727.

Courtenay. J.S.. Dallman, M.J., Dayan, A.D., Martin, A.. Mosedale, B. (1980). Immunization against
heterologous type 11 collagen induces arthritis in mice. Nature 283:666-667.

Fujii. K., Tsuji, M., Kitamura, A., Murota. K. (1992). The diagnostic significance of anti-type II collagen antibody
assay in rheumatoid arthritis. Int. Orthop. 16:272-276.

Gay, S., Gay R.E. and Miller, E.J. (1980). The collagens of the joint. Arthritis Rheum. 23:937-941.

Gioud, M.. MeghtaoOi. A., Costa. O., Monier. J.C. (1962). Antibodies of native type I and II collagens detected
by an enzyme linked immunosorbent assay (ELISA) in rheumatoid arthritis and systemic lupus erythematosus.
Collagen Rel. Res. 2:557-564. .

Heinegard. D. and Paulsson, M. (1987). Methods Enzymol. 145:336-363.

Hochberg. M.C. (1981). Adult and Juvenile rheumatoid arthritis: current epidemiologic concepts. Epidemiol.
Rev. 3:27-44.

Miller, E.J. (1985). The structure of fibril<forming collagens. Ann. N.Y. Acad. Sci. 460:1-13.

Miller. E.J. and Lunde. L.G. (1973). Isolation and characterization of the cyanogen bromide peptides from the
alpha-l(ll) chain of bovine and human cartilage collagen. Biochem 12:3153-3159.

Miller, E.J. and Rhodes, R.K. (1982). Preparation and characterization of the different types of collagen. Meth.
Enzymol. 82:33-64.

Morgan. K.. Clague. R.B.. Collins. I.. Ayad. S.. Phinn, 5.D.. Holt. P.J.L. (1987). Incidence of antibodies to
native and denature cartilage collagens (types II. IX, and XI) and to type I collagen in rheumatoid arthritis. Ann.
Rheum. Dis. 46:902-907.

Morgan. K.. Clague. R.B., Collins. I., Ayad, S., Phinn. S.D., Holt, P.J.L. (1989). A longitudinal study of
anticollagen antibodies in patients with rheumatoid arthritis. Arthritis Rheum. 32:139-145.

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INFORMATION DISCLOSURE CITATION

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Andrew COOK et al.

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OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc)

Perelra. R.S., Black. CM.. Duance. V.C.. Jones, V.E.. Jacoby, R.K.. Welsh, K.I. (1985) Disappearing collagen
antibodies in rheumatoid arthritis. Lancet // :501-502.

Piez, K.A. (1976). Primary structure. In Biochemistry of collagen. Ramchandran, G.H. and Reddl. A.N. (eds).
Plenum, New Yoric. pp 1-44.

Piez. K.A. (1982). Structure and assembly of the native collagen fibril. Connect Tissue Res. 10:25-36.

Rosenberg. A.M.. Hunt. D.W.C.. Pretty. R.E. (1984). Antibodies to native and denatured type 11 collagen in
children with rheumatic diseases. J. Rheumatol. 11:425-431.

Rowley, M.J.. Gershwin, M.E.. Mackay, I.R. (1988). Collagen antibodies in juvenile arthritis and adult
rheumatoid arthritis: differences in levels and type-specificity. J. Rheumatol. 15:289-294.

Rowley, M.J., Mackay, I.R., Brand. C.A.. Bateman, J.F.. Chan. 0. (1992). Epitope specificity of antibodies of
type II collagen in rheumatoid arthritis and systemic lupus erythematosus. Rheumatol. Int. 12:65-69

Scott. P.G. and Veis. A. (1976) The cyanogen bromide peotides of bovine soluble and insoluble collagens.
Connect Tissue Res. 4:107-116.

Stuart. J.M.. Huffstutter. E.H., Townes. A.S.. Kang. A.H. (1983). Incidence and specificity of antibodies to types
I. II, III. IV and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125 I-
radioimmunoassay. Arthritis Rheum. 26:832-840.

Steffen. C. TimpI R. (1963). Antigenicity of collagen and its application in the serological investigation of
rheumatoid arthritis sera. Int Arch. Allergy Appt. Immunol 22:333-349.

* * 2

Stockman. A.. Rowley. M.J., Emery. P.. Muirden, K.D. (1989). Activity of rheumatoid arthritis and levels of
collagen antibodies: a prospective study. Rheumatol. Int. 8:239-243

Terato. K. Cremer, M.A., Hasty, K.A.. Kang, A.H., Hasty, D.L. Townes. A.S. (1985). Physicochemical and
immunological studies of the renatured alpha 1(11) chains and isolated cyanogen bromide peptides of type II
collagen. Coll. Rel. Res. 5:469-480.

Terato. K., Shimozuru. Y., Katayama, K.. Takemitsu. Y.. Yamashila. 1.. Miyatsu, M.. Fujii. K., Sagara, M.,
Kobayashi. S.. Goto, M.. Nishioka. K.. Miyatsaka. N.. Nagai. Y. (1990). Specificity of antibodies of type M
collagen in rheumatoid arthritis. Arthritis Rheum 33:1493-1500.

Trentham, D.E. Townes, A.S., Kang, A.H. (1977). Autoimmunity to type II collagen: an experimental model of
arthritis. J. Exp. Med. 146:857-868.

002.1147358.1

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INFORMATION DISCLOSURE CITATION
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017227/0197

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Andrew COOK et al.

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OTHER DOCUMENTS (Including Author. Title. Date, Pertinent Pages. Etc.)

Trentham. D.E. Kammer, G.M., McCune, W.J.. David. J.R, (1981). Autoimmunity to collagen. A shared feature
of psoriatic and rheumatoid arthritis. Arthritis Rheum. 24:1363-1369.

Wericmeister, J.A., Ramshaw. J.A. M (1991). Multiple antigenic determinants on type III collagen. Biochem J.
274:895-898.

002.1147358.1